Just having a quick look at the CSS for the new Last FM design to see they’ve made great use of min-width, max-width and an inline css expression to create their pseudo-fluid layout. Those techniques have been in the toolkit for a long time, of course, but it’s only recently that browsers with reliable support have allowed web developers to wield them effectively.
Another excellent point of note is that their submit buttons are proper submit buttons, not some captured usability train wreck in the name of Web 2.0 that fails to work outside of the big three or four browsers. (Yes, Twitter, I’m looking at you.)
It’s good to see a small-ish company like Last FM create clean and usable site with intelligent code, whilst the likes of Yahoo! stumble about making their My Yahoo! pages increasingly unusable on anything other than a PC. Well done to them. 🙂